How much more does tirzepatide cost than semaglutide?

About $85 a month at the middle of the 27 companies that price both — but it runs from nothing at all to $152, and at one company tirzepatide is the cheaper of the two. The spread is the finding.

How much more is tirzepatide?

A median of $85 a month. 25 of the 27 companies charge more for tirzepatide, 1 charges the same, and 1 charges less. That last one has a label attached and it is dealt with below rather than dropped.

Is the gap the same everywhere?

No, and it is not even close. The premium runs from $30 at Mochi Health to $152 at Zealthy. As a ratio it runs from 0.8× to 1.84×.

Where is tirzepatide not more expensive?

At two companies, and both have an explanation printed in the table beside them. Enhance MD sells a microdosing tirzepatide plan at $169 a month described on its own card as 1 mg a week, and that is cheaper than its $212 full-dose semaglutide. It is a smaller dose of the more expensive molecule, not a cheaper version of it, and this site takes no clinical position on whether that dose does the same job.

Found charges the same $199 for both, and the rung label says why: it is Found's with-insurance monthly plan, a program price rather than a medication price. Found's own pricing page puts cash-pay monthly plans at $289.

What is this gap actually measuring?

The company's pricing decision, not the drug's cost. Every figure here is compounded medication from a pharmacy, sold on a subscription, with the visit and usually the shipping folded in. What varies between the two columns at one company is what that company chose to charge for the dual agonist, and the fact that the choice ranges from nothing to $152 tells you it is a positioning decision rather than a pass-through.

It is also the reason a premium quoted as a percentage travels better than one quoted in dollars. The median ratio here is 1.5×, and that ratio holds much more steadily across the roster than any dollar figure does.

Does the cheapest semaglutide seller have the cheapest tirzepatide?

At the top of the table, yes — the cheapest single month of compounded semaglutide and the cheapest single month of compounded tirzepatide are both CoreAge Rx, at $99 and $149. Below that the two orders diverge quickly, and a shortlist built on one molecule is not a shortlist for the other. That is the subject of whether the cheapest company is cheapest for the drug you need.

The other thing worth checking before comparing two rows here is whether the two companies are selling the same amount of time. Several price a four-week supply and call it a month, which changes a year by a whole extra charge — the billing-unit piece works that through.

What this comparison refuses to do

It refuses to cross a company boundary, and it refuses to average away the range. It also refuses to compare doses: the two rungs in a row are each that company's cheapest single month, and where those are different dose steps the labels say so. A like-for-like milligram comparison would need a dose ladder for both molecules at every company, and 4 of these 27 rows name a dose at all.

And it says nothing clinical. Which molecule is appropriate for anyone is a question for a prescriber; there is no clinician on this masthead and we do not invent one.

What else do people ask about the two molecules' prices?

• How much more does compounded tirzepatide cost than compounded semaglutide?A median of $85 a month across the 27 companies here that price both and can sell you either for a single month, read on August 31, 2026. The range runs from $30 at Mochi Health to $152 at Zealthy — which is why this piece prints the spread rather than an average.
• Is tirzepatide ever cheaper than semaglutide at the same company?Once, and the reason is in the rung label. Enhance MD's cheapest single month of tirzepatide is a microdosing plan at $169 a week-by-week 1 mg dose, against $212 for its full-dose semaglutide. Found is the only company here charging exactly the same for both, and its $199 is a with-insurance plan rate rather than a cash price.
• Which company has the cheapest tirzepatide?CoreAge Rx, at $149 for a single month with no commitment on August 31, 2026, which is also the cheapest semaglutide on the roster at $99. That is unusual: being cheapest on one molecule normally says nothing about the other, and the two league tables reorder heavily below the top.
• Why not just compare the cheapest semaglutide anywhere to the cheapest tirzepatide anywhere?Because that measures two companies, not two molecules. A cross-company subtraction would fold in every difference in membership, dose, billing unit and first-month discount between them. Every row here is one company's own two prices, read on the same day off the same site, which is the only version of this comparison that means anything.

The figures, with the sentences behind them

14 of the 27 pairs carry the seller's own sentence behind both figures, with the URL it was read on and the date. Those quotations live on the rung itself in this site's roster and are checked character for character against the company's record before this page can build.

Some companies named here pay us a commission when a reader starts care through a marked link. The one marked link on this page is one of them, picked by rule and disclosed beside it. Nothing above is ordered by who pays — the table is ordered by the size of the difference, and every figure is read out of the roster. Who pays us · how we review · every review.

Kevin Turner · Reviews Editor · Checked August 2026